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AmdU (5-Azidomethyl-2'-deoxyuridine)

貨號 數量 價格 交貨時間
B1540 5 mg $120 現貨
D1540 25 mg $255 現貨
F1540 100 mg $890 現貨
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Azidomethyl-dU (AmdU) is a nucleoside that contains an azide group. The structure of the nucleoside is similar to thymidine, and it is incorporated into nascent DNA by cellular polymerases, similar to EdU.

In contrast to EdU which needs to be further modified with azides in the presence of the copper catalyst, AmdU can also react in the absence of copper catalyst using SPAAC click chemistry with strained cycloalkynes, such as cyclooctynes. This enables the detection of nascent DNA in benign, copper-free conditions.

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Cyclooctyne derivative of fluorescein (FAM) for copper-free click chemistry reaction with azides. Pure 6-isomer of fluorescein.

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Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.

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General properties

Appearance: white / off white solid
Molecular weight: 283.24
CAS number: 59090-48-1
Molecular formula: C10H13N5O5
IUPAC name: 5-Azidomethyl-2'-deoxyuridine
Solubility: in water, alcohols, DMSO, DMF
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
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