Activated esters (bifunctional)
Primary or secondary amino groups are ubiquitous in biomolecules. They are present in proteins and peptides as ε-amino groups of lysines and N-terminal amino groups. Many natural and synthetic small molecules are amines, and DNAs with amino groups can be prepared by solid phase synthesis, and enzymatically.
Amino groups can be modified by acylation with various activated carbonyl compounds. Among these compounds, activated N-hydroxysuccinimide esters are most suitable for biolabeling and bioconjugation applications.
Compared to other activated esters, NHS derivatives possess good stability in aqueous environment. Optimal pH for the coupling of amines with NHS esters in aqueous buffers is 8.3-8.5. Labeling is also possible in organic solvents. Polar aprotic solents, such as DMF or DMSO, are preferred. One equivalent of tertiary amine base, such as triethylamine, or diisopropylethylamine (DIPEA) is necessary to achieve efficient amine acylation in non-aqueous solution.
3-馬來醯亞胺丙酸NHS-酯 (3-Maleimidopropionic acid NHS-ester)
具有胺反應性琥珀醯亞胺酯和巰基反應性的馬來醯亞胺基團的雙功能交聯劑。| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 3419-100mg | 100 mg | – | 現貨 | |
| 3419-500mg | 500 mg | $110 | 現貨 |
Alkyne-PEG2-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 2219-1g | 1 g |
$450
|
現貨 | |
| 2219-5g | 5 g |
$980
|
現貨 |
Alkyne-PEG3-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 2298-1g | 1 g |
$490
|
現貨 | |
| 2298-5g | 5 g |
$980
|
現貨 |
Alkyne-PEG4-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 2409-100mg | 100 mg | $250 | 現貨 | |
| 2409-1g | 1 g |
$790
|
現貨 |
Azide-PEG6-NHS ester
A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 3692-250mg | 250 mg | $325 | 現貨 | |
| 3692-1g | 1 g |
$539
|
現貨 |
Azidobutyric acid NHS ester
Activated NHS ester for azido-labeling of peptides and proteins.| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 53720 | 50 mg | $110 | 現貨 | |
| 63720 | 100 mg | $210 | 現貨 | |
| 73720 | 1 g |
$950
|
現貨 | |
| 83720 | 5 g | 請查詢 | 現貨 |
Biotin-PEG4-NHS ester
PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 2893-100mg | 100 mg | $145 | 現貨 | |
| 2893-1g | 1 g |
$590
|
現貨 |
DBCO NHS 酯
偶氮二苯並環辛炔 (DBCO、ADIBO) 試劑用於應變促進的無銅點擊化學 (SPAAC)。該試劑含有 NHS 酯官能團，用於將環辛炔連接到各種分子上。| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 34720 | 10 mg | $80 | 現貨 | |
| 44720 | 25 mg | $110 | 現貨 | |
| 54720 | 50 mg | $135 | 現貨 | |
| 64720 | 100 mg | $210 | 現貨 | |
| 94720 | 1 g |
$1000
|
現貨 | |
| K4720 | 5 g |
$3570
|
現貨 |
DBCO-PEG6-NHS ester
A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 3664-10mg | 10 mg | – | 現貨 | |
| 3664-50mg | 50 mg | $247 | 現貨 | |
| 3664-100mg | 100 mg |
$449
|
現貨 | |
| 3664-1g | 1 g |
$3490
|
5 天 |
DBCO STP酯 (DBCO STP ester)
一種活化酯用於蛋白質/抗體/肽的修飾，引入到無銅點擊化學反應。| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 2584-5mg | 5 mg | – | 5 天 | |
| 2584-10mg | 10 mg | $90 | 5 天 | |
| 2584-25mg | 25 mg | $180 | 現貨 | |
| 2584-100mg | 100 mg |
$450
|
5 天 | |
| 2584-500mg | 500 mg |
$1700
|
現貨 | |
| 2584-1g | 1 g |
$3000
|
現貨 | |
| 2584-5g | 5 g | 請查詢 | 現貨 |
Disuccinimidyl glutarate (DSG)
Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 4018-100mg | 100 mg | $95 | 現貨 | |
| 4018-1g | 1 g |
$410
|
現貨 |
Exo-BCN-PNP
BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 4043-100mg | 100 mg | $280 | 現貨 | |
| 4043-500mg | 500 mg |
$990
|
現貨 |
Hexynoic acid NHS ester
Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 41720 | 25 mg | $95 | 現貨 | |
| 51720 | 50 mg | $180 | 現貨 | |
| 61720 | 100 mg | $290 | 現貨 | |
| 91720 | 1 g | 請查詢 | 現貨 |
Hexynoic acid STP ester
Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 569-25mg | 25 mg | $95 | 現貨 | |
| 569-100mg | 100 mg | $185 | 現貨 | |
| 569-500mg | 500 mg |
$850
|
現貨 |
戊烯酸STP酯 (Pentynoic acid STP ester)
一種活化酯, 用於將炔基引入肽/蛋白質和連結反應。| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 30720 | 10 mg | $110 | 5 天 | |
| 40720 | 25 mg | $210 | 現貨 | |
| 50720 | 50 mg |
$410
|
現貨 | |
| 60720 | 100 mg |
$595
|
5 天 |
TCO-PEG4-NHS ester (axial isomer)
A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 3056-10mg | 10 mg | $145 | 現貨 | |
| 3056-25mg | 25 mg | $225 | 現貨 | |
| 3056-100mg | 100 mg |
$550
|
現貨 |
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