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Abasic phosphoramidite

貨號 數量 價格 交貨時間
3009-250mg 250 mg $179 現貨
3009-1g 1 g $358 5 天
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A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.

Cleavage of the N-glycosyl bond between a base and its 2-deoxyribose moiety in DNA generates an apurinic/apyrimidinic (so-called abasic) site. This phenomenon, which is referred to as depurination or depyrimidination occurs spontaneously under physiological conditions.

Abasic phosphoramidites are used in DNA and oligonucleotide synthesis. Abasic phosphoramidite imitates the loss of base pairing ability by a nucleotide. This modification of phosphoramidite is more stable than the natural abasic insert and can be used when examining DNA damage and repair.

Abasic phosphoramidite (dSpacer CE-Phosphoramidite) is a modification of 1',2'-dideoxyribose, contains a DMT protection of the hydroxymethyl group, and exhibits stability during synthesis and purification of oligonucleotides under standard conditions using AMA mixture, ammonium hydroxide / 40% methylamine (1:1).

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Alkyne dT phosphoramidite

Phosphoramidite modifier for synthesizing oligonucleotides containing alkyne modification in the middle of the chain.
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芘丁酸 (Pyrenebutyric acid)

含有游離羧酸官能團的芘衍生物。芘是一種多環芳烴(PAH),表現激發物螢光和對石墨的親和力。

Biotin-PEG4-azide

Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.

General properties

Appearance: white, off white to faint yellow viscous liquid
Molecular weight: 620.73
CAS number: 129821-76-7
Molecular formula: C35H45N2O6P
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格

Oligo synthesis details

Diluent: acetonitrile
Coupling conditions: standard coupling, identical to normal nucleobases
Deprotection conditions: identical to protected nucleobases
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