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Abasic phosphoramidite

Phosphoramidites

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3009-250mg	250 mg	$179	現貨
3009-1g	1 g	$358	現貨

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A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.

Cleavage of the N-glycosyl bond between a base and its 2-deoxyribose moiety in DNA generates an apurinic/apyrimidinic (so-called abasic) site. This phenomenon, which is referred to as depurination or depyrimidination occurs spontaneously under physiological conditions.

Abasic phosphoramidites are used in DNA and oligonucleotide synthesis. Abasic phosphoramidite imitates the loss of base pairing ability by a nucleotide. This modification of phosphoramidite is more stable than the natural abasic insert and can be used when examining DNA damage and repair.

Abasic phosphoramidite (dSpacer CE-Phosphoramidite) is a modification of 1′,2′-dideoxyribose, contains a DMT protection of the hydroxymethyl group, and exhibits stability during synthesis and purification of oligonucleotides under standard conditions using AMA mixture, ammonium hydroxide / 40% methylamine (1:1).

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C6 Spacer phosphoramidite

Spacer 6 phosphoramidite, commonly referred to as C6 spacer amidite, is a specialized reagent used in the synthesis of oligonucleotides. This compound incorporates a 6-carbon hydrophobic spacer into oligonucleotide sequences, either internally or at the 5' end.

FAM 亞磷酰胺，6-異構體 (FAM phosphoramidite, 6-isomer)

單一構體 6-FAM 亞磷酰胺，用於寡核苷酸的修飾。

General properties

Appearance:	white, off white to faint yellow oil
Molecular weight:	620.73
CAS number:	129821-76-7
Molecular formula:	C₃₅H₄₅N₂O₆P
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	下載
	產品規格

Oligo synthesis details

Diluent:	acetonitrile
Coupling conditions:	standard coupling, identical to normal nucleobases
Deprotection conditions:	identical to protected nucleobases

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.