此頁面上的某些內容不提供英文版本，將默認以當前可用的語言顯示。

Thalidomide-O-PEG2-azide

Azides PROTAC Crosslinking
貨號 數量 價格 交貨時間
4154-25mg 25 mg $189 現貨
4154-100mg 100 mg $489 現貨
批量詢價
Found better price? Let us know and we will propose the way forward!

Thalidomide-containing building block with PEG2-linker and azide function group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.

以
ChemDraw 格式下載

顧客還購買了這個產品

Thalidomide-O-PEG2-carboxylic acid

Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
将此产品添加到购物车并
立即在线获取免费快递服务证书

Thalidomide-carboxylic acid

Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.
将此产品添加到购物车并
立即在线获取免费快递服务证书

General properties

Appearance: off-white solid
Molecular weight: 431.41
Molecular formula: C19H21N5O7
Solubility: good in polar organic solvents: ethyl acetate, THF, DMF; poor in diethyl ether, water
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
已添加您的物品. 查看您的 购物车 或 继续结账
物品数量不正确.