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Thalidomide-carboxylic acid
| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 4169-100mg | 100 mg | $160 | 現貨 | |
| 4169-500mg | 500 mg |
$510
|
現貨 | |
| 4169-1g | 1 g |
$740
|
現貨 |
Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.
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Thalidomide-O-PEG2-azide
Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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Thalidomide-O-PEG2-carboxylic acid
Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
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General properties
| Appearance: | beige powder |
| Molecular weight: | 332.27 |
| CAS number: | 1061605-21-7 |
| Molecular formula: | C15H12N2O7 |
| Solubility: | DMF, DMSO |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | 下載 |
| 產品規格 |
Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.
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