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Thalidomide-O-PEG2-amine

Amines PROTAC
貨號 數量 價格 交貨時間
4401-100mg 100 mg $425 現貨
4401-250mg 250 mg $749 現貨
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Thalidomide-containing building block with PEG2-linker and amino group, which can be conjugated to other functionalized linkers and target protein ligands.

The amino group is highly reactive and can undergo reactions with carboxylic acids, activated esters (NHS, STP, etc.), carbonyls (such as ketones and aldehydes), and more.

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.

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沙利度胺-O-PEG2-疊氮化物 (Thalidomide-O-PEG2-azide)

含有沙利度胺的結構單元，具有 PEG2 連接體和疊氮官能團，可通過點擊化學反應與炔基連接體和靶蛋白配體偶聯。
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沙利度胺-O-PEG2-羧酸 (Thalidomide-O-PEG2-carboxylic acid)

含有沙利度胺的結構單元，具有 PEG2 連接子和羧基，用於與氨基連接子和目標蛋白配體偶聯。
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General properties

Appearance: white crystalline solid
Molecular weight: 441.86
CAS number: 1957236-10-0 (hydrochloride)
Molecular formula: C19H24ClN3O7
Solubility: DMF, DCM, methanol
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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