Perylene azide

該產品已停產，不再提供. 但我們有一些庫存（請參閱下方）

疊氮化物苝點擊化學

貨號	數量	價格	交貨時間
A5530	1 mg	請查詢	現貨 (2 pcs)
B5530	5 mg	請查詢	現貨 (2 pcs)
C5530	10 mg	請查詢	現貨 (3 pcs)
D5530	25 mg	請查詢	現貨 (2 pcs)
E5530	50 mg	請查詢	現貨 (2 pcs)

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This product will be discontinued soon. We may still have some material in stock (please see availability above).

Perylene is a bright and extremely photostable fluorescent polycyclic aromatic hydrocarbon (PAH) label with quantum yield approaching quantitative.

Due to low life time of fluorescence, this probe does not form excimers.

Perylene labeling of biomolecules is used to be difficult and tedious because of low solubility of perylene, and low availability of activated derivatives. However, labeling via Click Chemistry with this perylene azide is nearly as easy, as with other dyes. Labeling peptide, DNA, protein with this polyaromatic hydrocarbon has never been so simple yet.

To increase hydrophilicity, and facilitate labeling, this PAH azide contains hydrophilic triethyleneglycol linker.

以
ChemDraw 格式下載

General properties

Appearance:	orange-yellow solid
Molecular weight:	452.50
CAS number:	1807503-81-6
Molecular formula:	C₂₇H₂₄N₄O₃
IUPAC name:	3-(8-Azido-3,6-trioxaoctylaminocarbonyl)perylene
Solubility:	good in dichloromethane and chloroform, moderate in DMSO, DMF, and acetonitrile
Quality control:	NMR ¹H (95%)
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.
MSDS:	下載
	產品規格

Spectral properties

Excitation/absorption maximum, nm:	435; 408; 252
ε, L⋅mol⁻¹⋅cm⁻¹:	36000
Emission maximum, nm:	439; 467
Fluorescence quantum yield:	1.0

產品引用

Bednarczyk, M.; Peters, J.K.; Kasprzyk, R.; Starek, J.; Warminski, M.; Spiewla, T.; Mugridge, J.S.; Gross, J.D.; Jemielity, J.; Kowalska, J. Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. ACS Chemical Biology, 2022, 17(6), 1460-1471. doi: 10.1021/acschembio.2c00049
Epanchintseva, A. V.; Gorbunova, E. A.; Ryabchikova, E. I.; Pyshnaya, I. A.; Pyshnyi, D. V. Effect of Fluorescent Labels on DNA Affinity for Gold Nanoparticles. Nanomaterials, 2021, 11(5), 1178. doi: 10.3390/nano11051178
Taskova, M.; Astakhova, K. Fluorescent Oligonucleotides with Bis(prop-2-yn-1-yloxy)butane-1,3-diol Scaffold Rapidly Detect Disease-Associated Nucleic Acids. Bioconjugate Chemistry, 2019, 30(12), 3007–3012. doi: 10.1021/acs.bioconjchem.9b00746
Westergaard Mulberg, M.; Taskova, M.; Thomsen, R.P.; Okholm, A.H.; Kjems, J.; Astakhova, K. New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods. Chembiochem, 2017, 18(16), 1599–1603. doi: 10.1002/cbic.201700125