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Alkyne CPG modifier 500

Alkynes Oligonucleotide synthesis CPG modifier solid supports Click chemistry
貨號 數量 價格 交貨時間
12860 100 mg $60 現貨
22860 250 mg $120 現貨
32860 500 mg $230 現貨
42860 1 g $380 現貨
52860 5 g $1450 現貨
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High loading controlled pore glass solid support for the synthesis of oligonucleotides with 3'-alkyne group. With this solid support, synthesis of oligos of up to 50 bases is possible.

Terminal alkyne group can be modified by copper catalyzed Click chemistry (see our recommended protocol for oligonucleotide modification).

This solid support is compatible with standard oligonucleotide deblocking conditions. No special deblocking is required.

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General properties

Appearance: off-white beads
Quality control: NMR 1H and HPLC (95%) of bound reagent, loading measurement
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
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產品規格

Oligo synthesis details

Pore size, Å: 500
Typical loading, umol/g: 70−90
Coupling conditions: standard coupling, identical to normal nucleobases
Cleavage conditions: ammonia, 2 h at room temperature
Deprotection conditions: identical to protected nucleobases

產品引用

  1. Kolganova, N.A.; Tsvetkov, V.B.; Stomakhin, A.A.; Surzhikov, S.A.; Timofeev, E.N.; Varizhuk, I.V. Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer. International Journal of Molecular Sciences, 2023, 24(9), 8406. doi: 10.3390/ijms24098406
  2. Petrunina, N.A.; Lebedev, V.V.; Kirillova, Y.G.; Aralov, A..V.; Varizhuk, A.M.; Sardushkin, M.V. DNA Intercalated Motifs with Non-Nucleoside Inserts. Russian Journal of Bioorganic Chemistry, 2021, 47(6), 1341–1344. doi: 10.1134/S1068162021060212
  3. Svetlova, J.; Sardushkin, M.; Kolganova, N.; Timofeev, E. Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core. Biomolecules, 2021, 11(9), 1332. doi: 10.3390/biom11091332
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