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Exo-BCN-PNP

Cycloalkynes
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4043-100mg 100 mg $280 現貨
4043-500mg 500 mg $990 現貨
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BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate. Reaction conditions is similar to NHS-amino linkage but PNP ester provides less off-target hydrolysis and higher conjugation yield forming hydrolytically stable bond with substrate.

Bicyclononyne (BCN) is one of the most reactive cyclooctynes for copper-free click chemistry. Both exo- and endo- isomers are active and have near the same power of reactions konstants [1,2]. BCN reacts even faster than DBCO [1] with aromatic azides and comparing to dibenzofused systems has two advantages. First, it contains a plane of symmetry which prevents the formation of mixtures of stereoisomeric products. Second, BCN provides lower lipophilicity which is typically more beneficial when reaction is performed in aqueous solutions. Unlike DBCO, BCN reactivity is not only limited to azides (SPAAC) and nitrones (SPANC), but also covers tetrazines (IEDDA) [2] and more recently tetrazoles (photoclick) [3] providing exceptional reaction rates.

[1] Jan Dommerholt et al. Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells. Angewandte Chemie. 2010. 49(49). 9422-9425.

[2] Wagner et al. Origin of Orthogonality of Strain-Promoted Click Reactions. Chemistry. 2015. 21(35).12431-12435.

[3] Gangam Srikanth Kumar et al. Superfast Tetrazole–BCN Cycloaddition Reaction for Bioorthogonal Protein Labeling on Live Cells. Journal of the American Chemical Society. 2022. 144(1). 57-62.
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DBCO NHS 酯

偶氮二苯並環辛炔 (DBCO、ADIBO) 試劑用於應變促進的無銅點擊化學 (SPAAC)。該試劑含有 NHS 酯官能團，用於將環辛炔連接到各種分子上。

DBCO-PEG6-NHS ester

A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).

DBCO STP酯 (DBCO STP ester)

一種活化酯用於蛋白質/抗體/肽的修飾，引入到無銅點擊化學反應。

General properties

Appearance: off-white solid
Molecular weight: 315.32
Molecular formula: C17H17NO5
Solubility: good in DMF, DMSO, acetonitrile
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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