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DDTT Sulfurizing Reagent

貨號 數量 價格 交貨時間
3179-1g 1 g –   現貨
3179-5g 5 g $245 現貨
3179-25g 25 g $1150 現貨
3179-50g 50 g $1800 現貨
3179-100g 100 g 請查詢 現貨
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DDTT is a sulfurizing reagent used to prepare phosphorothioate linkages, which increase the stability and nuclease resistance of nucleic acids, especially of RNA. It is suitable for automated synthesizers employing standard phosphoramidites for a large-scale synthesis of oligonucleotides.

DDTT demonstrates faster kinetics and higher stability in solution, compared to other sulfurizing reagents such as tetraethylthiuram disulfide (TETD) and Beaucage reagent, respectively. DDTT is commonly applied as a 0.05 M or 0.1 M solution in pyridine/acetonitrile and has a lifetime of up to 6 months.

Usage

Coupling: Sulfurization step must come before capping step. The optimum sulfurizing time for DDTT Sulfurizing Reagent, 0.05 M solution in pyridine/acetonitrile: 1 min for DNA or 6 min for RNA.

Deprotection: standard conditions.

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通用 CPG II 型,1000A (Universal CPG type II, 1000A)

這種通用支持物旨在用於寡核苷酸的自動合成,以加速解封閉過程中的去磷酸化過程。對於多達 120 個堿基的寡核苷酸合成,建議使用 1000 Å 的孔徑。

General properties

Appearance: lemon yellow crystals
Molecular weight: 205.33
CAS number: 1192027-04-5
Molecular formula: C5H7N3S3
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格

Oligo synthesis details

Diluent: acetonitrile
Coupling conditions: standard coupling, identical to normal nucleobases
Deprotection conditions: identical to protected nucleobases
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