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Cyanine5 carboxylic acid

貨號	數量	價格	交貨時間
13090	1 mg	$110	現貨
23090	5 mg	$210	現貨
43090	25 mg	$410	現貨
53090	50 mg	$695	現貨
63090	100 mg	$1190	現貨

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Non-activated carboxylic acid, an analog of Cy5® free carboxylic acid. Contains Cyanine5 fluorophore.

This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. Water-soluble version is available.

This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration. For coupling with amines and protein labeling, consider using Cyanine5 NHS ester, or water-soluble sulfo-Cyanine5 NHS ester.

以
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General properties

Appearance:	dark golden solid
Molecular weight:	519.12
CAS number:	1032678-07-1 (chloride), 195867-59-5 (inner salt), 766503-38-2 (without anion)
Molecular formula:	C₃₂H₃₉ClN₂O₂
IUPAC name:	3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1,3,3-trimethyl-, chloride
Solubility:	soluble in organic solvents (DMF, DMSO, dichloromethane), very poorly soluble in water (0.25 mM, 130 mg/L)
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	下載
	產品規格

Spectral properties

Excitation/absorption maximum, nm:	646
ε, L⋅mol⁻¹⋅cm⁻¹:	250000
Emission maximum, nm:	662
Fluorescence quantum yield:	0.2
CF₂₆₀:	0.03
CF₂₈₀:	0.04

產品引用

Tchatchiashvilli, T.; Duering, H.; Mueller-Boetticher, L.; Grune, C.; Fischer, D.; Pletz, M.W.; Makarewicz, O. PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkolderia cenocepacia. Journal of Pharmaceutical Analysis, 2024. doi: 10.1016/j.jpha.2024.01.007
Yao, P.; Wang, X.; Wang, Q.; Dai, Q.; Peng, Y.; Yuan, Q.; Mou, N.; Lv, S.; Weng, B.; Wang, Y.; Sun, F. Cyclic RGD-Functionalized PH/ROS Dual-Responsive Nanoparticle for Targeted Breast Cancer Therapy. Pharmaceutics, 2023, 15(7), 1827. doi: 10.3390/pharmaceutics15071827
Lu, Y.; Zhou, J.; Wang, Q.; Cai, J.; Yu, B.; Dai, Q.; Bao, Y.; Chen, R.; Zhang, Z.; Zhang, D.; Hou, T. Glucocorticoid-Loaded PH/ROS Dual-Responsive Nanoparticles Alleviate Joint Destruction by Downregulating the NF-ΚB Signaling Pathway. Acta Biomaterialia, 2023, 164, 458–473. doi: 10.1016/j.actbio.2023.04.012
Rezaei, S.; de Araújo Júnior, R. F.; da Silva, I. L. G.; Schomann, T.; Eich, C.; Cruz, L. J. Erythrocyte−cancer Hybrid Membrane-Coated Reduction-Sensitive Nanoparticles for Enhancing Chemotherapy Efficacy in Breast Cancer. Biomaterials Advances, 2023, 151, 213456. doi: 10.1016/j.bioadv.2023.213456