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(S,R,S)-AHPC-PEG2-C2-azide

Azides Click chemistry Copper-free click chemistry PROTAC
貨號 數量 價格 交貨時間
4530-25mg 25 mg $189 現貨
4530-100mg 100 mg $529 現貨
4530-500mg 500 mg $1598 現貨
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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

(S,R,S)-AHPC-C2-azide is a protein degrader building block for the synthesis of molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an azide function group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

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沙利度胺-羧酸 (Thalidomide-carboxylic acid)

含有沙利度胺的結構單元，具有羧酸官能團，通過 4-O-位將功能化氨基接頭和配體連接到沙利度胺上，從而方便地組裝 PROTAC 分子。

沙利度胺-O-PEG2-羧酸 (Thalidomide-O-PEG2-carboxylic acid)

含有沙利度胺的結構單元，具有 PEG2 連接子和羧基，用於與氨基連接子和目標蛋白配體偶聯。
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沙利度胺-O-PEG2-疊氮化物 (Thalidomide-O-PEG2-azide)

含有沙利度胺的結構單元，具有 PEG2 連接體和疊氮官能團，可通過點擊化學反應與炔基連接體和靶蛋白配體偶聯。

General properties

Appearance: yellow glassy oil
Molecular weight: 615.75
CAS number: 2597167-22-9
Molecular formula: C29H41N7O6S
Solubility: methanol, ethyl acetate, DCM, THF, DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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