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LumiTracker® Mito JC-1

Cell viability and apoptosis Mitochondria Microscopy Flow cytometry Membrane potential measurement
貨號 數量 價格 交貨時間
2275-50ug 50 ug –   現貨
2275-1mg 1 mg $110 現貨
2275-5mg 5 mg $150 現貨
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JC-1 is a cationic carbocyanine dye that accumulates in the mitochondria of live cells in a potential-dependent manner.

The dye exists as a green-fluorescent monomer at depolarized membranes and low concentrations. At higher concentrations (aqueous solutions above 0.1 µM) and hyperpolarized membranes, the dye forms J-aggregates that exhibit an emission at the orange channel.

Healthy cells have high mitochondrial membrane potential, and the decrease of mitochondrial membrane potential is a marker of the early stage of apoptosis. All this allows the use of changes in the orange/green fluorescence ratio of JC-1 to determine healthy vs. depolarized mitochondria. The orange/green fluorescence ratio of JC-1 depends only on the mitochondrial membrane potential and not on other factors such as the size, shape, and density of mitochondria.

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General properties

Appearance: red-purple solid
Molecular weight: 652.24
CAS number: 47729-63-5; 3520-43-2
Molecular formula: C25H27Cl4IN4
IUPAC name: 1H-Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-, iodide
Solubility: good in DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格

產品引用

  1. Katkova, S.A.; Bunev, A.S.; Gasanov, R.E.; Khochenkov, D.A.; Kulsha, A.V.; Ivashkevich, O.A.; Serebryanskaya, T.V.; Kinzhalov, M. Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer. Chem. Eur. J., 2024, e202400101. doi: 10.1002/chem.202400101
  2. Kirsanov, R.S.; Khailova, L.S.; Rokitskaya, T.I.; Lyamzaev, K.G.; Panteleeva, A.A.; Nazarov, P.A.; Firsov, A.M.; Iaubasarova, I.R.; Korshunova, G.A.; Kotova, E.A.; Antonenko, Y.N. Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Di tert -butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler. ACS Omega, 2024, 9(10), 11551-11561. doi: 10.1021/acsomega.3c08621
  3. Menchinskaya, E. S.; Chingizova, E. A.; Pislyagin, E. A.; Yurchenko, E. A.; Klimovich, A. A.; Zelepuga, E. A.; Aminin, D. L.; Avilov, S. A.; Silchenko, A. S. Mechanisms of Action of Sea Cucumber Triterpene Glycosides Cucumarioside A0-1 and Djakonovioside A Against Human Triple-Negative Breast Cancer. Marine Drugs, 2024, 22(10), 474. doi: 10.3390/md22100474
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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