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Cyanine7.5 azide

Cyanine7.5 Azides Click chemistry Near infrared (NIR) imaging

貨號	數量	價格	交貨時間
16030	100 uL, 10 mM/DMSO	–	現貨
36030	500 uL, 10 mM/DMSO	$199	現貨
46030	1 mL, 10 mM/DMSO	$495	現貨
A6030	1 mg	–	現貨
B6030	5 mg	$199	現貨
C6030	10 mg	$297	現貨
D6030	25 mg	$495	現貨
E6030	50 mg	$895	現貨
F6030	100 mg	$1490	現貨

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Cyanine7.5 is a NIR dye with long-wave infrared fluorescence. This derivative is azide for click chemistry.

Can be used for the construction of various labeled biomolecules containing Cyanine7.5, near-infrared fluorescent dye, and an improved analog of Cy7.5®. These conjugates can take advantage of NIR tissue transparency when used for in vivo imaging. This fluorophore is also useful for other fluorescent applications, especially requiring low fluorescent background.

Azide is available as a DMSO solution, ready for general click chemistry labeling protocol, or in solid form for custom labeling applications.

Structure features a rigid bridged polymethine chain to increase quantum yield by 20%, allowing for a brighter signal.

以
ChemDraw 格式下載

General properties

Appearance:	green powder / solution
Molecular weight:	767.44
CAS number:	1628790-36-2; 1628897-78-8 (without anion)
Molecular formula:	C₄₈H₅₅ClN₆O
Solubility:	soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	下載
	產品規格

Spectral properties

Excitation/absorption maximum, nm:	788
ε, L⋅mol⁻¹⋅cm⁻¹:	223000
Emission maximum, nm:	808
Fluorescence quantum yield:	0.10

產品引用

Hellyer, S.D.; Aggarwal, S.; Chen, A.N.; Leach, K.; Lapinsky, D.J.; Gregory, K.J. Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes. ACS Chemical Neuroscience, 2020, 11(11), 1597–1609. doi: 10.1021/acschemneuro.0c00009
Retout, M.; Brunetti, E.; Valkenier, H.; Bruylants, G. Limits of thiol chemistry revealed by quantitative analysis of mixed layers of thiolated-PEG ligands grafted onto gold nanoparticles. Journal of Colloid and Interface Science, 2019, 557, 807–815. doi: 10.1016/j.jcis.2019.09.047
Pearce, H.A.; Qian, H.; Connell, T.U.; Huang, D.; Gottstein, C.; Donnelly, P.S.; Peter, K.; Gregorevic, P.; Hagemeyer, C.E. Site-specific glycation and chemo-enzymatic antibody sortagging for the retargeting of rAAV6 to inflamed endothelium. Molecular Therapy - Methods & Clinical Development, 2019, 14, 261–269. doi: 10.1016/j.omtm.2019.07.003
Kong, J.-N.; Zhu, Z.; Itokazu, Y.; Wang, G.; Dinkins, M.B.; Zhong, L.; Lin, H.-P.; Elsherbini, A.; Leanhart, S.; Jiang, X.; Qin, H.; Zhi, W.; Spassieva, S.D.; Bieberich, E. Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes. Journal of Lipid Research, 2018, 59(3), 488–506. doi: 10.1194/jlr.M081877