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Cyanine7 NHS ester

Cyanine7 NHS esters Protein labeling Near infrared (NIR) imaging

貨號	數量	價格	交貨時間
15020	1 mg	$125	現貨
25020	5 mg	$260	現貨
45020	25 mg	$510	現貨
55020	50 mg	$895	現貨
65020	100 mg	$1490	現貨

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Amine reactive Cyanine7, near infrared fluorescent dye, an improved analog of Cy7®.

NIR fluorophores can be used to take advantage of near infrared window of biological tissues - increased transparency of tissues in this spectral region allows to carry out in vivo imaging.

This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments.

The structure of Cyanine7 features rigidized design of central polymethyne chain. This molecular reinforcement allows to increase quantum yield by 20% compared with parent structure, increasing fluorescence brightness.

This reagent requires organic co-solvent for the labeling (please see Recommended Protocols section below). Water-soluble Cyanine7 NHS ester is also available, and recommended for protein NIR labeling.

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General properties

Appearance:	dark green solid
Molecular weight:	733.64
CAS number:	2408482-09-5
Molecular formula:	C₄₁H₄₈N₃BF₄O₄
Solubility:	soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	下載
	產品規格

Spectral properties

Excitation/absorption maximum, nm:	750
ε, L⋅mol⁻¹⋅cm⁻¹:	199000
Emission maximum, nm:	773
Fluorescence quantum yield:	0.3
CF₂₆₀:	0.022
CF₂₈₀:	0.029

產品引用

Ehrman, R.N.; Brohlin, O.R.; Wijesundara, Y.H.; Kumari, S.; Trashi, O.; Howlett, T.S.; Trashi, I.; Herbert, F.C.; Raja, A.; Koirala, S.; Tran, N.; Al-Kharji, N.M.; Tang, W.; Senarathna, M.C.; Hagge, L.M.; Smaldone, R.A.; Gassensmith, J.J. A scalable synthesis of adjuvanting antigen depots based on metal–organic frameworks. Chemical Science, 2024, 15(8), 2731-2744. doi: 10.1039/d3sc06734c
Seo, H.S.; Han, J.-H.; Lim, J.; Bae, G.-H.; Byun, M.J.; Wang, C.-P.J.; Han, J.; Park, J.; Park, H.H.; Shin, M.; Park, T.-E.; Kim, T.-H.; Kim, S.-N.; Park, W.; Park, C.G. Enhanced Post-Surgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy. Biomaterials Research, 2024, 28, 0008. doi: 10.34133/bmr.0008
Ehrman, R. N.; Brohlin, O. R.; Wijesundara, Y. H.; Kumari, S.; Trashi, I.; Trashi, O.; Howlett, T. S.; Herbert, F. C.; Raja, A.; Koirala, S.; Tran, N.; Al-Kharji, N. M.; Hagge, L. M.; Gassensmith, J. A Scalable Synthesis of Adjuvanting Antigen Depots Based on Met-al-Organic Frameworks. ChemRxiv, 2023, preprint. doi: 10.26434/chemrxiv-2023-gtl30
Itzhaki, E.; Chausky-Barzakh, E.; Atkins, A.; Bareket-Samish, A.; Stemmer, S. M.; Margel, S.; Moskovits, N. Tumor-Targeted Poly(ArgGlyAsp) Nanocapsules for Personalized Cancer Therapy – In Vivo Study. Advanced Therapeutics, 2023, 6(6), 2200337. doi: 10.1002/adtp.202200337