3-(5-methyl-1H-pyrazol-3-yl)propionic acid-d6 (MPP)
| 貨號 | 數量 | 價格 | 交貨時間 | 購買此產品 |
|---|---|---|---|---|
| 4337-500ug | 0.50 mg | $259 | 12 天 |
Succinylacetone-pyrazole-d6 is a deuterated derivative of succinylacetone-pyrazole (SA-pyrazole-d6) and is used as an analytical standard in the measurement of succinylacetone (SA). Succinylacetone is a reactive diketone and reacts with the amino groups of amino acid residues of peptides and proteins present in the blood.
As a result, in order to extract the immobilized SA, it must be converted into a more highly stable product, which is subsequently subjected to extraction, namely a pyrazole derivative.
SA content in tandem mass spectrometry (MSMS) analysis is defined as the content of the derivative compound, 3-(5-methyl-1H-pyrazol-3-yl)propanoic acid (MPP). SA is quantified by adding a stable isotope-labeled propanoic acid analogue as an internal standard.
Succinylacetone is a product of tyrosine catabolism and an inhibitor of heme biosynthesis. Succinylacetone (SA) testing in dried neonatal blood spots, followed by quantitation of SA in blood or urine in high-risk neonates, has excellent sensitivity and specificity for the diagnosis of tyrosinemia type 1 [1]. Succinylacetone also serves as a tool for studying the defects of heme synthesis on cellular processes.
[1] Kehar M., Sen Sarma M., Seetharaman J., Jimenez Rivera C., Chakraborty P. Decoding hepatorenal tyrosinemia type 1: Unraveling the impact of early detection, NTBC, and the role of liver transplantation. Can Liver J. 2024. 7(1). P.54-63.
General properties
| Appearance: | white solid |
| Molecular weight: | 160.21 |
| Molecular formula: | C7H4D6N2O2 |
| Solubility: | in water |
| Quality control: | NMR 1H and HPLC-MS (95+ %, D: 98+ %) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | 下載 |
| 產品規格 |
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