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Melatonin-d3

貨號 數量 價格 交貨時間
4287-500ug 0.50 mg $44 12 天
4287-5mg 5.0 mg $238 7 天
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Melatonin-d3 is a deuterium-labeled stable isotopic analogue of the main pineal gland hormone, used as standards in NMR spectroscopy and mass spectrometry.

Melatonin takes part in the regulation of sleep, the activity of the endocrine system, circulatory and immune systems, and its pronounced antioxidant effect is also known. Replacing hydrogen atoms with its stable isotope, deuterium, allows absorption, distribution and metabolism to be determined in in vivo experiments [1]. The use of melatonin-d3 as a standard for mass spectrometry made it possible to accurately determine the melatonin content in biological fluids, such as blood plasma [2], urine [1], breast milk [3].

[1] Leone R.M. and Silman R.E. Melatonin can be differentially metabolized in the rat to produce N-acetylserotonin in addition to 6-hydroxy-melatonin. Endocrinology. 1984. 114(5). P.1825-1832.

[2] Zhao H., et al. A novel LC-MS/MS assay for the simultaneous determination of melatonin and its two major metabolites, 6-hydroxymelatonin and 6-sulfatoxymelatonin in dog plasma: Application to a pharmacokinetic study. J Pharm Biomed Anal. 2016. 117. P. 390-397.

[3] Jin W., et al. High-throughput quantitation of trace level melatonin in human milk by on-line enrichment liquid chromatography-tandem mass spectrometry. Anal Chim Acta. 2021. 1176:338764.
以
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General properties

Appearance: gray solid
Molecular weight: 235.30
CAS number: 90735-69-6
Molecular formula: C13H13D3N2O2
IUPAC name: N-(2-(5-methoxy-1H-indol-3-yl)ethyl)acetamide-2,2,2-d3
Solubility: Acetonitrile, DMSO
Quality control: NMR 1H and HPLC-MS (95+ %, D: 98+ %)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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