此頁面上的某些內容不提供英文版本，將默認以當前可用的語言顯示。

LumiTracker® Mito JC-1

Mitochondria Cell viability and apoptosis Membrane potential measurement Microscopy Flow cytometry
貨號 數量 價格 交貨時間
2275-50ug 50 ug –   現貨
2275-1mg 1 mg $110 現貨
2275-5mg 5 mg $150 現貨
樣品請求
Found better price? Let us know and we will propose the way forward!

JC-1 is a cationic carbocyanine dye that accumulates in the mitochondria of live cells in a potential-dependent manner.

The dye exists as a green-fluorescent monomer at depolarized membranes and low concentrations. At higher concentrations (aqueous solutions above 0.1 µM) and hyperpolarized membranes, the dye forms J-aggregates that exhibit an emission at the orange channel.

Healthy cells have high mitochondrial membrane potential, and the decrease of mitochondrial membrane potential is a marker of the early stage of apoptosis. All this allows the use of changes in the orange/green fluorescence ratio of JC-1 to determine healthy vs. depolarized mitochondria. The orange/green fluorescence ratio of JC-1 depends only on the mitochondrial membrane potential and not on other factors such as the size, shape, and density of mitochondria.

以
ChemDraw 格式下載

顧客還購買了這個產品

Hoechst S769121 (黃色細胞核染料)，黃色螢光核酸染色劑 [Hoechst S769121 (Nuclear Yellow), yellow fluorescent nucleic acid stain]

Hoechst S769121是一種細胞滲透性的黃色雙鏈 DNA 螢光染料，用於對活細胞和固定細胞中的 DNA進行染色。

BDP® 630/650 hydrazide

A carbonyl reactive borondipyrromethene based dye for the red channel (Cyanine5).

LumiTracker® Mito Orange CM-H2TMRos

一種陽離子橙色螢光染料，用於對活細胞中的活性線粒體進行染色。CM-H2TMRos 是 CMTMRos 染料的還原型非螢光版本，在線粒體膜氧化時會發出螢光。

General properties

Appearance: red-purple solid
Molecular weight: 652.24
CAS number: 47729-63-5; 3520-43-2
Molecular formula: C25H27Cl4IN4
IUPAC name: 1H-Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-, iodide
Solubility: good in DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格

產品引用

  1. Katkova, S.A.; Bunev, A.S.; Gasanov, R.E.; Khochenkov, D.A.; Kulsha, A.V.; Ivashkevich, O.A.; Serebryanskaya, T.V.; Kinzhalov, M. Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer. Chem. Eur. J., 2024, e202400101. doi: 10.1002/chem.202400101
  2. Kirsanov, R.S.; Khailova, L.S.; Rokitskaya, T.I.; Lyamzaev, K.G.; Panteleeva, A.A.; Nazarov, P.A.; Firsov, A.M.; Iaubasarova, I.R.; Korshunova, G.A.; Kotova, E.A.; Antonenko, Y.N. Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Di tert -butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler. ACS Omega, 2024, 9(10), 11551-11561. doi: 10.1021/acsomega.3c08621
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
已添加您的物品. 查看您的 購物車 或 繼續結賬
物品數量不正確.