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(E/Z)-4-Hydroxytamoxifen

貨號 數量 價格 交貨時間
3669-10mg 10 mg $60 現貨
3669-50mg 50 mg $209 現貨
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(E/Z)-4-Hydroxytamoxifen (4-OHT, cis/trans-4-hydroxytamoxifen, afimoxifene) is a selective estrogen receptor (ER) modulator, an active metabolite of tamoxifen. 4-Hydroxytamoxifen is widely used as a research tool for inducible genome manipulation.

4-Hydroxytamoxifen is used in the inducible Cre-LoxP system to control CreER/CreERT2 recombinase activity and trigger tissue-specific gene expression or genome/genetic modification (e.g., gene deletion). 4-Hydroxytamoxifen is a part of the TRAP/TRAP2 (targeted recombination in active populations) systems providing genetic access to neuron activity. It is also used in CRISPR/Cas9 gene editing to activate inactivated Cas9 nuclease.

Also, 4-Hydroxytamoxifen was reported to be an intramembranous lipid peroxidation inhibitor, exhibiting peroxyl radical scavenging activity.

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Cyanine7炔烴 (Cyanine7 alkyne)

Cyanine7 alkyne 是一種用於點擊化學的近紅外 (NIR) 染料炔烴。
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DMF(二甲基甲酰胺), 標籤級 (DMF (dimethylformamide), labeling grade)

即用型高純度、無胺溶劑,用於 NHS 酯標記。

抗壞血酸 (Ascorbic acid)

抗壞血酸是一種還原劑,可將銅 (II) 轉化為用於催化點擊反應的一價形式。

General properties

Appearance: white solid
Molecular weight: 387.52
CAS number: 68392-35-8
Molecular formula: C26H29NO2
IUPAC name: 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
Solubility: DMF, Ethanol, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: 下載
產品規格

產品引用

  1. Thi Duy Ngoc, N.; Yurchenko, E. A.; Thi Hoai Trinh, P.; Menchinskaya, E. S.; Thi Dieu, T. V.; Savagina, A. D.; Minin, A.; Thinh, P. D.; Khanh, H. H. N.; Thi Thanh Van, T.; Yurchenko, A. N. Secondary Metabolites of Vietnamese Marine Fungus Penicillium Chermesinum 2104NT-1.3 and Their Cardioprotective Activity. Regional Studies in Marine Science, 2024, 104003. doi: 10.1016/j.rsma.2024.104003
  2. Leshchenko, E.V.; Chingizova, E.A.; Antonov, A.S.; Shlyk, N.P.; Borkunov, G.V.; Berdyshev, D.V.; Chausova, V.E.; Kirichuk, N.N.; Khudyakova, Y.V.; Chingizov, A.R.; Kalinovsky, A.I.; Popov, R.S.; Kim, N.Y..; Chadova, K.A.; Yurchenko, E.A.; Isaeva, M.P.; Yurchenko, A.N. New Zosteropenillines and Pallidopenillines from the Seagrass-Derived Fungus Penicillium Yezoense KMM 4679. Marine Drugs, 2024, 22(7), 317. doi: 10.3390/md22070317
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