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(E/Z)-4-Hydroxytamoxifen

神經科學 ROS傳感

貨號	數量	價格	交貨時間	購買此產品
3669-10mg	10 mg	$60	現貨
3669-50mg	50 mg	$209	現貨

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(E/Z)-4-Hydroxytamoxifen (4-OHT, cis/trans-4-hydroxytamoxifen, afimoxifene) is a selective estrogen receptor (ER) modulator, an active metabolite of tamoxifen. 4-Hydroxytamoxifen is widely used as a research tool for inducible genome manipulation.

4-Hydroxytamoxifen is used in the inducible Cre-LoxP system to control CreER/CreERT2 recombinase activity and trigger tissue-specific gene expression or genome/genetic modification (e.g., gene deletion). 4-Hydroxytamoxifen is a part of the TRAP/TRAP2 (targeted recombination in active populations) systems providing genetic access to neuron activity. It is also used in CRISPR/Cas9 gene editing to activate inactivated Cas9 nuclease.

Also, 4-Hydroxytamoxifen was reported to be an intramembranous lipid peroxidation inhibitor, exhibiting peroxyl radical scavenging activity.

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General properties

Appearance:	white solid
Molecular weight:	387.52
CAS number:	68392-35-8
Molecular formula:	C₂₆H₂₉NO₂
IUPAC name:	4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
Solubility:	DMF, Ethanol, DMSO
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	下載
	產品規格

產品引用

Thi Duy Ngoc, N.; Yurchenko, E. A.; Thi Hoai Trinh, P.; Menchinskaya, E. S.; Thi Dieu, T. V.; Savagina, A. D.; Minin, A.; Thinh, P. D.; Khanh, H. H. N.; Thi Thanh Van, T.; Yurchenko, A. N. Secondary Metabolites of Vietnamese Marine Fungus Penicillium Chermesinum 2104NT-1.3 and Their Cardioprotective Activity. Regional Studies in Marine Science, 2025, 81, 104003. doi: 10.1016/j.rsma.2024.104003
Leshchenko, E.V.; Chingizova, E.A.; Antonov, A.S.; Shlyk, N.P.; Borkunov, G.V.; Berdyshev, D.V.; Chausova, V.E.; Kirichuk, N.N.; Khudyakova, Y.V.; Chingizov, A.R.; Kalinovsky, A.I.; Popov, R.S.; Kim, N.Y..; Chadova, K.A.; Yurchenko, E.A.; Isaeva, M.P.; Yurchenko, A.N. New Zosteropenillines and Pallidopenillines from the Seagrass-Derived Fungus Penicillium Yezoense KMM 4679. Marine Drugs, 2024, 22(7), 317. doi: 10.3390/md22070317

Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.